Core Concepts

Theoretical frameworks for understanding aging and longevity.

Overview

This section covers the fundamental conceptual frameworks that help us understand how aging works at a systems level.

Concepts

• De-Darwinization - How evolution suppresses evolution within organisms
• Death Pact - The multicellular contract limiting cellular autonomy
• Replicative Credit - Investment in high-fidelity DNA replication
• SCANDAL Hypothesis - Why sea creatures die when cells could survive
• Principal-Agent Problem - Managing 37 trillion cellular agents